Potential Deleterious Effects Following the First Dose of Medroxyprogesterone Acetate as a Contraceptive in Cats

The aim of the present work was to investigate deleterious effects first dose medroxyprogesterone acetate (MPA) on female genital system cats. study conducted 315 cats different breeds who received their (75 mg) MPA as a contraceptive. Complete animal identification and stage estrus were documented at admission. Physical, radiographic ultrasonographic examinations done that expressed manifestations. All presented an overdose during estrous phase cycle. Out MPA, 27 (8.6 %) demonstrated varied related system. Deleterious reported within 15–90 days, including pyometra (n=10, 37.0%), endometritis (n=8, 29.6%), mammary gland hyperplasia (n=4, 14.8 %), cystic endometrial (n=3, 11.2%) ovarian cyst (n=2, 7.4%). incidence these adverse increased with age. Persian seem be more susceptible than other cat breeds. Long haired following injection exogenous progestins short (Siamese Egyptian mau). occurred overdose. It is advised use contraceptive in recommended inter-estrous or anestrous phase.